![]() ![]() Aspirin at high concentrations of 10 and 20 mminhibited de novo protein synthesis as demonstrated by inhibition of methionine incorporation into total islet protein and by inhibition of rabbit reticulocyte expression by Brome mosaic virus mRNA, suggesting that inhibition of iNOS expression at these high concentrations of aspirin may be due to the impairment of the translational machinery. Aspirin (1–5 mm) did not affect insulin secretion at basal or glucose-stimulated conditions, whereas higher concentrations of aspirin (10–20 mm) significantly increased basal insulin secretion. The effects of aspirin on islet function were examined by measuring glucose-stimulated insulin secretion in the presence of various concentrations of aspirin. Therapeutic concentrations of aspirin (1–5 mm) that block NO production affected neither nuclear factor-κB activation nor inducible NO synthase (iNOS) mRNA transcription but potently inhibited iNOS protein expression by both RINm5F cells and rat islets. In this study, we examined the effects of aspirin on production of nitric oxide (NO), a proinflammatory mediator, and show that aspirin inhibits NO production by transformed pancreatic β cells (RINm5F) and rat islets in a concentration-dependent manner with an IC50 value of ∼3 mm. Mechanisms of action for these drugs, however, are not clearly understood. Louis, Missouri 63110Īspirin and aspirin-like drugs are the most commonly indicated agents for the treatment of inflammation. I think this is the science behind the "no aspirin" concept:Įffects of Aspirin on Nitric Oxide Formation and De Novo Protein Synthesis by RINm5F Cells and Rat Isletsĭepartment of Pathology, Washington University School of Medicine, St. cold or flu, ASA or at least some aspirin product such NSAIDS or tylenol. What do people take when they have a fever i.e. Hence, your body temp will be slightly elevated. Remember, with ephedra you get a thermogenic effect. Future studies should focus on the long-term efficacy of the ECA combination, and the effects of stopping treatment on the maintenance of fat loss.I asked Dave P this a while back and he stated the same thing. Most studies have also demonstrated the incidence of short-term side effects associated with excessive sympathetic stimulation, and have shown them to be transient and mild. Randomized placebo-controlled trials have demonstrated the short-term efficacy of the ECA combination, but long-term studies are lacking. ![]() In rat studies, the mechanism of action has been well characterized in vitro and although there is some discrepancy in humans, a similar mechanism seems to be active. This protein-sparing lipolysis has been attributed to the elevated levels of cAMP generated by the ECA combination. Recent studies have demonstrated that treating patients with a drug combination including the sympathomimetic ephedrine, the stimulant caffeine, and the analgesic aspirin (ECA combination) will stimulate thermogenesis and result in lowered weight but maintained muscle mass. For the past twenty years the thermogenic effects of sympathetic stimulation have been known and described. The field of obesity management is coming to appreciate the efficacy of pharmacological treatments. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |